{"id":1288,"date":"2024-12-30T15:05:00","date_gmt":"2024-12-30T15:05:00","guid":{"rendered":"https:\/\/retina-eye.co.uk\/?p=1288"},"modified":"2026-03-26T18:33:52","modified_gmt":"2026-03-26T18:33:52","slug":"hydroxychloroquine-retinotoxicity-do-i-need-to-be-monitored","status":"publish","type":"post","link":"https:\/\/www.retina-eye.co.uk\/zh\/post\/hydroxychloroquine-retinotoxicity-do-i-need-to-be-monitored\/","title":{"rendered":"\u7f9f\u57fa\u6c2f\u55b9Retinotoxicity\u2013\u6211\u9700\u8981\u53d7\u5230\u76d1\u6d4b\uff1f"},"content":{"rendered":"

\u4ec0\u4e48\u662f\u7f9f\u57fa\u6c2f\u55b9?<\/h2>\n\n\n\n

\u7f9f\u57fa\u6c2f\u55b9\u662f\u4e00\u4e2a\u4e3b\u8981\u7684\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u548c\u9884\u9632\u759f\u75be\u3002 \u5b83\u4e5f\u88ab\u7528\u5728\u51e0\u4e2a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff1a\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u7ea2\u6591\u72fc\u75ae\uff0c\u535f\u5549\u75c7cutanea tarda,Srojen\u7efc\u5408\u75c7\u3002 \u6570\u636e\u5e93\u53d1\u8868\u7684\u7814\u7a76\u7684\u5927\u5b66\u56fd\u738b\u5b66\u9662\u533b\u9662\u7684\u98ce\u6e7f\u75c5\u90e8\u95e8\u4e0e3 000\u540d\u60a3\u8005\u4f30\u8ba1\u8d85\u8fc735%\u7684\u60a3\u8005\u662f\u5728\u8fd9\u79cd\u6cbb\u7597\u3002 (1)<\/p>\n\n\n\n

\u662f\u7f9f\u57fa\u6c2f\u55b9\u4f7f\u7528\u6709\u5bb3\u7684\u773c\u775b\uff1f<\/h2>\n\n\n\n

\u6700\u8fd1\u7684\u6d41\u884c\u75c5\u5b66\u7684\u6570\u636e\u8868\u660e\uff0c\u666e\u904d\u7684\u6bd2\u6027\u4e4b\u95f4\u957f\u671f(5\u5e74)\u7f9f\u57fa\u6c2f\u55b9\u7684\u7528\u6237\u7ea6\u4e3a7.5%. \u8fd9\u79cd\u98ce\u9669\u589e\u52a0\u523020-50%\u4e4b\u540e\u768420\u5e74\u4e2d\uff0c\u8fd9\u53d6\u51b3\u4e8e\u4e2a\u4eba\u7684\u98ce\u9669\u56e0\u7d20\u3002 (2)\u5728\u4e00\u4e2a\u5206\u5f00\u6211\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u6d41\u884c\u7387 \u7f9f\u57fa\u6c2f\u55b9\u75c5\u89c6\u7f51\u819c\u75c5\u53d8<\/u><\/a> \u88ab\u53d1\u73b0\u662f0.48%\u7684\u60a3\u8005\u5728\u670d\u7528\u5242\u91cf\u4e3a\u5927\u4e8e6.5\u6beb\u514b\/\u5343\u514b\/\u5929\u3002 (3) <\/p>\n\n\n\n

\u7687\u5bb6\u5b66\u9662\u7684\u773c\u79d1\u533b\u751f\u7684\u6307\u5357\u5efa\u8bae\uff0c\u53ea\u6709\u76d1\u6d4b\u540e5\u5e74\u7684\u6cbb\u7597\uff0c\u9274\u4e8e\u53ea\u67094%\u7684\u60a3\u8005\u5f00\u59cb\u7f9f\u57fa\u6c2f\u55b9\u7ee7\u7eed\u5728\u8fd9\u8d85\u8fc75\u5e74\u3002<\/p>\n\n\n\n

\u4ec0\u4e48\u662f\u5df2\u77e5\u7684\u5371\u9669\u56e0\u7d20\u7f9f\u57fa\u6c2f\u55b9Retinotoxicity?<\/h2>\n\n\n\n

\u4e0e\u8f83\u9ad8\u6bd2\u6027\u98ce\u9669\u76f8\u5173\u7684\u56e0\u7d20\u5305\u62ec\uff1a <\/p>\n\n\n\n

    \n
  1. \u75c5\u4eba\u5bf9\u6c2f\u55b9\u6216\u9ad8\u5242\u91cf\u7f9f\u57fa\u6c2f\u55b9(>5mg\/\u516c\u65a4\/\u65e5)\u3002\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n\n\n\n
  2. \u60a3\u6709\u80be\u75c5\u548c\u80be\u529f\u80fd\u53d7\u635f(\u4f30\u8ba1\u80be\u5c0f\u7403\u6ee4\u7387\u4f4e\u4e8e60\/min\/1.73m2)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n\n\n\n
  3. \u60a3\u8005 \u4ed6\u6cbb\u7597<\/u><\/a>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n<\/ol>\n\n\n\n

    \u6709\u4ec0\u4e48\u8ff9\u8c61\u7684\u7f9f\u57fa\u6c2f\u55b9Retinotoxicity?<\/h2>\n\n\n\n

    \u4ee5\u524d\uff0c \u89c6\u7f51\u819c\u75c5\u53d8<\/u><\/a> \u68c0\u6d4b\u540e\u60a3\u8005\u51fa\u73b0\u75c7\u72b6\uff0c\u7531\u5176\u5c31\u4e0d\u4f1a\u6709\u76f8\u5f53\u5927\u7684\u4e0d\u53ef\u9006\u8f6c\u7684\u89c6\u7f51\u819c\u4e0a\u76ae\u7ec6\u80de\u8272\u7d20\u7684\u635f\u5bb3\u3002 \u5728\u4e34\u5e8a\u4e0a\uff0c\u8fd9\u5df2\u7ecf\u88ab\u63cf\u8ff0\u4e3a\u4e00\u4e2a\u5178\u578b\u7684parafoveal\u6a21\u5f0f\u7684RPE\u635f\u5931\u6216 \u516c\u725b\u7684\u773c\u775b\u9ec4\u6591\u75c5\u53d8<\/u><\/a>.  <\/p>\n\n\n\n

    \u8fd9\u901a\u5e38\u662f\u4e0eparacentral\u4e9b\u9886\u57df\u635f\u5931\u548c\u901a\u5e38\u5f71\u54cd\u4e24\u53ea\u773c\u775b\u3002(4)\u6b64\u5916\uff0c\u97e9\u56fd\u7814\u7a76\u5df2\u7ecf\u53d1\u73b0pericentral\u635f\u5bb3\u60a3\u8005\u7684\u4e9a\u6d32\u65cf\u88d4\u3002 (5)\u7684\u7814\u7a76\u663e\u793a\u7ee7\u7eed\u6076\u5316\u7684\u89c6\u89c9\u529f\u80fd\u60a3\u8005RPE\u635f\u5bb3\u7684\u5927\u7ea63\u5e74\u751a\u81f3\u4e4b\u540e\u505c\u6b62\uff0c\u836f\u7269\u3002 (4)<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u6211\u4eec\u5982\u4f55\u68c0\u67e5\u6216\u76d1\u6d4b\u5bf9\u7f9f\u57fa\u6c2f\u55b9Retinotoxicity?<\/h2>\n\n\n\n

    \u51fa\u73b0\u4e86\u5927\u91cf\u7684\u6210\u50cf\u65b9\u5f0f\uff0c\u4f8b\u5982\u5149\u8c31\u57df\u6708\uff0c\u5e7f\u89d2\u8272\u7684\u773c\u5e95\u6444\u5f71\u548c\u773c\u5e95\u8367\u5149\u73b0\u5728\u5141\u8bb8\u9884\u5148\u5bf9\u75c7\u68c0\u6d4b\u7684RPE\u635f\u574f\u548c\u4fee\u6539\u6216\u505c\u6b62\u6cbb\u7597\u3002 \u65e9\u671f\u8bca\u65ad\u4f1a\u56e0\u6b64\u9650\u5236\u53d1\u5c55\u7684\u4f7f\u4eba\u8870\u5f31\u7684\u89c6\u91ce\u635f\u5931\u3002  <\/p>\n\n\n\n

    \u4e3b\u8981\u76ee\u7684\u662f\u8fdb\u884c\u4efb\u4f55\u76d1\u6d4b\u7a0b\u5e8f\u4e0d\u662f\u4e3a\u4e86\u9632\u6b62\u7f9f\u57fa\u6c2f\u55b9\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\uff0c\u4f46\u68c0\u6d4b\u7684\u6700\u65e9\u660e\u786e\u7684\u8ff9\u8c61\uff0c\u9884\u5148\u5bf9\u75c7\u6bd2\u6027\u3002 \u8fd9\u5c06\u6709\u52a9\u4e8e\u4fc3\u8fdb\u77e5\u60c5\u7684\u51b3\u7b56\u8fc7\u7a0b\u4e4b\u95f4\u7684\u60a3\u8005\u5f00\u5904\u65b9\u533b\u5e08\u5728\u63d0\u4f9b\u6cbb\u7597\u65b9\u6848\u4ee5\u53ca\u98ce\u9669\u548c\u76ca\u5904\u3002 <\/p>\n\n\n\n

    \u95f4\u63a5\u7684\uff0c\u8fd9\u5c06\u51cf\u5c11\u7684\u6bd4\u4f8b\u53ef\u907f\u514d\u7684\u89c6\u635f\u5bb3\u5728\u8be5\u5c0f\u7ec4\u7684\u60a3\u8005\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u4ec0\u4e48\u662f\u6c2f\u55b9\uff0c\u5b83\u662f\u6709\u5bb3?<\/h2>\n\n\n\n

    \u6c2f\u55b9\u662f\u76f8\u5173\u7684\u53d1\u75c5\u7387\u66f4\u9ad8\u7684\u6709\u6bd2\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u65f6\u76f8\u6bd4\uff0c\u7f9f\u57fa\u6c2f\u55b9\uff1b\u4ee5\u53ca\u5f88\u5c11\u4f7f\u7528\uff0c\u5728\u4e34\u5e8a\u5b9e\u8df5\u3002 \u6307\u5bfc\u5b89\u5168\u7684\u914d\u91cf\uff0c\u8868\u660e\u5242\u91cf\u4f4e\u4e8e2.3\u6beb\u514b\/\u5343\u514b\u6bcf\u5929\u5bf9\u6c2f\u55b9\u3002 \u56e0\u4e3a\u98ce\u9669\u8f83\u9ad8\u7684\u89c6\u7f51\u819c\u6bd2\uff0c\u60a3\u8005\u5e94\u8be5\u52a0\u4ee5\u7b5b\u9009\u6bcf\u5e74\u4e00\u6b21\u3002(6\u548c7)<\/p>\n\n\n\n

    \u5982\u679c\u4f60\u662f\u5728\u7f9f\u57fa\u6c2f\u55b9\u6216\u6c2f\u55b9\uff0c\u5b83\u5c06\u5ba1\u614e\u786e\u4fdd\u4f60\u6709\u4e00\u5e74\u4e00\u5ea6\u7684\u5c4f\u5e55\u4e0e\u533b\u7597\u7684\u89c6\u7f51\u819c\u7684\u4e13\u5bb6\u3002<\/p>\n\n\n\n

    Ms\u6c99\u9f99\u6052<\/u><\/a> \u662f\u533b\u5b66\u7684\u89c6\u7f51\u819c\u7684\u4e13\u5bb6\u548c\u719f\u7ec3\u7684\u767d\u5185\u969c\u5916\u79d1\u533b\u751f\u3002 \u5979\u662f\u4e00\u540d\u4e13\u5bb6\u5728\u89c6\u7f51\u819c\u9ec4\u6591\u75be\u75c5\u548c\u5df2\u8bbe\u7f6e\u7684\u7f9f\u57fa\u6c2f\u55b9\u7684\u6570\u5b57\u76d1\u6d4b\u9014\u5f84\u548c\u8bc4\u4f30\u5458\u7684\u57f9\u8bad\u6a21\u5757\uff0c\u5728\u6469\u83f2\u773c\u79d1\u533b\u9662\u7684\u57ce\u5e02\u7684\u9053\u8def\u3002 <\/p>\n\n\n\n

    \u79c1\u4eba\u54a8\u8be2\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec <\/a>info@retina-eye.co.uk<\/u><\/a> <\/p>\n\n\n\n

    \u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n

      \n
    1. \u7687\u5bb6\u5b66\u9662\u7684\u773c\u79d1\u533b\u751f\u7684\u7f9f\u57fa\u6c2f\u55b9\u7684\u7b5b\u9009\u51c6\u5219\u67082020\u5e74<\/li>\n\n\n\n
    2. Melles RB\uff0cMarmor MF\u3002 \u5371\u9669\u6709\u6bd2\u75c5\u89c6\u7f51\u819c\u75c5\u60a3\u8005\u7684\u957f\u671f\u7f9f\u57fa\u6c2f\u55b9\u7684\u6cbb\u7597\u3002 \u8d3e\u9a6c\u773c\u79d1\u3002 2014;132(12):1453-60<\/li>\n\n\n\n
    3. \u5f81GD\uff0cMunz SJ,\u5e15J,Cohen HB,\u5939\u9f3b\u773c\u955cKJ,\u5f7c\u5f97\u68eeT.\u53d1\u751f\u7684\u7f9f\u57fa\u6c2f\u55b9\u7684\u89c6\u7f51\u819c\u75c5\u57281207\u4e2a\u60a3\u8005\u5728\u4e00\u4e2a\u5927\u591a\u4e2d\u5fc3\u95e8\u8bca\u505a\u6cd5\u3002 \u5173\u8282\u708e\u3001\u98ce\u6e7f. 1997;40(8):1482-6.<\/li>\n\n\n\n
    4. Marmor MF,\u80e1J.\u5f71\u54cd\u7684\u75be\u75c5\u7684\u9636\u6bb5\u8fdb\u5c55\u7684\u7f9f\u57fa\u6c2f\u55b9\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u3002 \u8d3e\u9a6c\u773c\u79d1\u3002 2014;132(9):1105-12<\/li>\n\n\n\n
    5. \u674eDH\uff0cMelles RB\uff0c\u4e54SG\u674eJY,Kim JG\uff0c\u674eCK,et al. Pericentral\u7f9f\u57fa\u6c2f\u55b9\u7684\u89c6\u7f51\u819c\u75c5\u5728\u97e9\u56fd\u7684\u60a3\u8005\u3002 \u773c\u79d1\u3002 2015\u5e74;122(6):1252-6<\/li>\n\n\n\n
    6. Finbloom DS\uff0c\u94f6K\uff0c\u7ebd\u745f\u59c6\u8fbe\uff0cGunkel R.\u6bd4\u8f83\u7684\u7f9f\u57fa\u6c2f\u55b9\u548c\u4f7f\u7528\u6c2f\u55b9\u548c\u53d1\u5c55\u7684\u89c6\u7f51\u819c\u7684\u6bd2\u6027\u3002 \u8be5\u6742\u5fd7\u7684\u98ce\u6e7f\u75c5. 1985;12(4):692-4.<\/li>\n\n\n\n
    7. \u5170\u65af\u798f\u5fb7KD\uff0cParke AL\uff0c\u514b\u5229\u798f\u5fb7-Rashotte\u7c73\uff0c\u80af\u6069WF\u3002 \u6cbb\u7597\u548c\u836f\u7406\u5b66\u7279\u6027\u7684\u7f9f\u57fa\u6c2f\u55b9\u548c\u6c2f\u55b9\u5728\u5904\u7406\u7684\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u98ce\u6e7f\u6027\u5173\u8282\u708e\u548c\u6709\u5173\u7684\u75be\u75c5\u3002 Inflammopharmacology. 2015\u5e74\u3002<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

      What is Hydroxychloroquine? Hydroxychloroquine is a major drug used for treatment and prevention of malaria. It is also used in several autoimmune diseases: rheumatoid arthritis, lupus, and porphyria cutanea tarda, Srojen syndrome. A database study published by King\u2019s college hospital rheumatology department with 3,000 patients estimates that more than 35% of their patients are on […]<\/p>\n","protected":false},"author":1,"featured_media":1289,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-1288","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t